Development of a new synthetic route to Chiral Diene Ligands

• Main Author: Shi, Qi
• Other Authors: Hayashi Tamio
• Format: Final Year Project
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
• Online Access: http://hdl.handle.net/10356/76185
• Institution: Nanyang Technological University

Catalytic asymmetric synthesis of a chiral diene ligand with a C2-symmetric norbornadiene as scaffold was developed. The ligand precursor with high enatioselectivity was achieved by rhodium-catalyzed asymmetric three-component reaction. Large scale reactions were conducted in this project, and the r...