Activated bioadhesives for bone repair

The use of pins, screws and plates to stabilise fractured bones involve excessive drilling of holes into bones. Drilling of holes can result in osteolysis due to the increase in local temperature of the surrounding tissues. This project explores the use of a UV-activated diazirine bioadhesives in bo...

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Main Author: Thng, Jeanette Jun Ting
Other Authors: Terry W. J. Steele
Format: Final Year Project
Language:English
Published: 2019
Subjects:
Online Access:http://hdl.handle.net/10356/76762
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-767622023-03-04T15:35:40Z Activated bioadhesives for bone repair Thng, Jeanette Jun Ting Terry W. J. Steele School of Materials Science and Engineering DRNTU::Engineering::Materials The use of pins, screws and plates to stabilise fractured bones involve excessive drilling of holes into bones. Drilling of holes can result in osteolysis due to the increase in local temperature of the surrounding tissues. This project explores the use of a UV-activated diazirine bioadhesives in bone repair surgery. Activated diazirine bioadhesive provides surgeons with better control of the onset of crosslinking and allows surgeons to adjust the strength of adhesion based on surrounding tissues. Transparent rods were inserted into bovine cortical bone to mimic pin fixation on human bone where the bioadhesive was subsequently light activated. Optical testing was done prior to the tests to assess the intensity of UV light transmitted through the transparent rods. Compression lap shear tests were also conducted after activation of the bioadhesive to determine the strength of adhesion of the bioadhesive on bones. The lap shear strength at failure obtained from the tests was 25kPa which demonstrates proof-of-concept application and can be further explored for use in orthopaedic. Bachelor of Engineering (Materials Engineering) 2019-04-09T05:16:40Z 2019-04-09T05:16:40Z 2019 Final Year Project (FYP) http://hdl.handle.net/10356/76762 en Nanyang Technological University 41 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Materials
spellingShingle DRNTU::Engineering::Materials
Thng, Jeanette Jun Ting
Activated bioadhesives for bone repair
description The use of pins, screws and plates to stabilise fractured bones involve excessive drilling of holes into bones. Drilling of holes can result in osteolysis due to the increase in local temperature of the surrounding tissues. This project explores the use of a UV-activated diazirine bioadhesives in bone repair surgery. Activated diazirine bioadhesive provides surgeons with better control of the onset of crosslinking and allows surgeons to adjust the strength of adhesion based on surrounding tissues. Transparent rods were inserted into bovine cortical bone to mimic pin fixation on human bone where the bioadhesive was subsequently light activated. Optical testing was done prior to the tests to assess the intensity of UV light transmitted through the transparent rods. Compression lap shear tests were also conducted after activation of the bioadhesive to determine the strength of adhesion of the bioadhesive on bones. The lap shear strength at failure obtained from the tests was 25kPa which demonstrates proof-of-concept application and can be further explored for use in orthopaedic.
author2 Terry W. J. Steele
author_facet Terry W. J. Steele
Thng, Jeanette Jun Ting
format Final Year Project
author Thng, Jeanette Jun Ting
author_sort Thng, Jeanette Jun Ting
title Activated bioadhesives for bone repair
title_short Activated bioadhesives for bone repair
title_full Activated bioadhesives for bone repair
title_fullStr Activated bioadhesives for bone repair
title_full_unstemmed Activated bioadhesives for bone repair
title_sort activated bioadhesives for bone repair
publishDate 2019
url http://hdl.handle.net/10356/76762
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