Optimization of drug release profile for 2D and 3D electrospun fibres for liver fibrosis
The increasing trend of liver-related diseases has resulted in numerous cases of death and is currently highly ranked in terms of deadly diseases. Therefore, more focus has been put on finding a solution for the various type of liver diseases. All liver diseases progress through liver fibrosis de...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/76777 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | The increasing trend of liver-related diseases has resulted in numerous cases of death and is
currently highly ranked in terms of deadly diseases. Therefore, more focus has been put on
finding a solution for the various type of liver diseases. All liver diseases progress through
liver fibrosis defined by scar tissue formation. With the fast development of health-related
researches, many methods have been proposed to overcome the symptoms of liver fibrosis.
However, there are many limitations to the present methods. One of the methods that had
recently come into the spotlight is the use of electrospinning to fabricate fibre to prepare
scaffolds for drug delivery.
Our current work investigates the effects of electrospinning on the fabricated fibre and the
process of encapsulating Decorin in the electrospun fibre for release study and full
encapsulation study. There is also the use of BSA as the protein to optimise the encapsulation
percentage within the electrospun fibre. Characterization method like Micro BCA Assay,
ELISA Assay, spectrophotometry and scanning electron microscopy (SEM) will be
employed. |
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