Characterization of the splicing functions of the two pseudouridines Ψ5 and Ψ6 in U1 small nuclear RNA

• Main Author: Tan, Darren Wei
• Other Authors: Francesc Xavier Roca Castella
• Format: Final Year Project
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/77190
• Institution: Nanyang Technological University

Pseudouridylation is the most abundant type of Ribonucleic acid (RNA) modification where uracil is converted into pseudouridine (Ψ). The 5’ end of U1 small nuclear RNA (snRNA) contains two evolutionary conserved pseudouridines, Ψ5 and Ψ6. It is still a challenge to understand the splicing roles of Ψ...