Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2)

• Main Author: Ng, Xin Yi
• Other Authors: Yoon Ho Sup
• Format: Final Year Project
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/77391
• Institution: Nanyang Technological University

Parkinson’s Disease (PD), a disease of old age, is the second most common neurodegenerative disease which remains incurable despite many attempts to discover a cure. This study focuses on Nurr1, an orphan nuclear receptor, due to its essential role in the survival and maintenance of dopaminergic neu...