Investigating the role of de novo designed peptides in ameliorating amylin aggregation and β-cell toxicity in Type 2 Diabetes (T2D)

• Main Author: Gupta, Gaytri
• Other Authors: Surajit Bhattacharyya
• Format: Final Year Project
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/77435
• Institution: Nanyang Technological University

Pancreatic β-cell dysfunction and apoptosis in Type 2 Diabetes (T2D) is associated with amylin aggregation and amyloid deposition. Current strategies targeting amyloidogenesis include the use of inhibitory peptides, segments of amylin sequence with “breaker elements”, to disrupt the aggregation proc...