Investigating the role of de novo designed peptides in ameliorating amylin aggregation and β-cell toxicity in Type 2 Diabetes (T2D)
Pancreatic β-cell dysfunction and apoptosis in Type 2 Diabetes (T2D) is associated with amylin aggregation and amyloid deposition. Current strategies targeting amyloidogenesis include the use of inhibitory peptides, segments of amylin sequence with “breaker elements”, to disrupt the aggregation proc...
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| 格式: | Final Year Project |
| 語言: | English |
| 出版: |
2019
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| 在線閱讀: | http://hdl.handle.net/10356/77435 |
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| 機構: | Nanyang Technological University |
| 語言: | English |