Investigation into surface plasmon resonance based optical sensor

This project seeks to use simple and inexpensive materials and methods to fabricate a micro-fluidic unit for the purpose of developing a lab-on-chip optical biosensor. The biosensor uses the principle of grating-coupled Surface Plasmon Resonance (SPR) to detect the change in concentration of sucrose...

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Main Author: Leong, Joseph Jun Yih
Other Authors: Murukeshan Vadakke Matham
Format: Final Year Project
Language:English
Published: 2019
Subjects:
Online Access:http://hdl.handle.net/10356/77659
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-776592023-03-04T19:02:06Z Investigation into surface plasmon resonance based optical sensor Leong, Joseph Jun Yih Murukeshan Vadakke Matham School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering This project seeks to use simple and inexpensive materials and methods to fabricate a micro-fluidic unit for the purpose of developing a lab-on-chip optical biosensor. The biosensor uses the principle of grating-coupled Surface Plasmon Resonance (SPR) to detect the change in concentration of sucrose solution. The experimental data from the SPR response can be used to validate and evaluate the performance of the microfluidic unit by observing the shift in the SPR curves. The micro-fluidic unit is created from the curing of Polydimethylsiloxane (PDMS) and then tested with a gold diffraction grating film on silicon wafer, which is created using interference lithography process. Preliminary results indicate that the mould type, size of micro-fluidic channel and design of the unit greatly affect its performance. Experiments involving the testing of the micro-fluidic units were performed over using a broadband white light, beam-splitter, polarizer and spectrometer, which was connected to the PC. The signal response was then evaluated using Ocean view software. Bachelor of Engineering (Mechanical Engineering) 2019-06-03T13:58:14Z 2019-06-03T13:58:14Z 2019 Final Year Project (FYP) http://hdl.handle.net/10356/77659 en Nanyang Technological University 62 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Mechanical engineering
spellingShingle DRNTU::Engineering::Mechanical engineering
Leong, Joseph Jun Yih
Investigation into surface plasmon resonance based optical sensor
description This project seeks to use simple and inexpensive materials and methods to fabricate a micro-fluidic unit for the purpose of developing a lab-on-chip optical biosensor. The biosensor uses the principle of grating-coupled Surface Plasmon Resonance (SPR) to detect the change in concentration of sucrose solution. The experimental data from the SPR response can be used to validate and evaluate the performance of the microfluidic unit by observing the shift in the SPR curves. The micro-fluidic unit is created from the curing of Polydimethylsiloxane (PDMS) and then tested with a gold diffraction grating film on silicon wafer, which is created using interference lithography process. Preliminary results indicate that the mould type, size of micro-fluidic channel and design of the unit greatly affect its performance. Experiments involving the testing of the micro-fluidic units were performed over using a broadband white light, beam-splitter, polarizer and spectrometer, which was connected to the PC. The signal response was then evaluated using Ocean view software.
author2 Murukeshan Vadakke Matham
author_facet Murukeshan Vadakke Matham
Leong, Joseph Jun Yih
format Final Year Project
author Leong, Joseph Jun Yih
author_sort Leong, Joseph Jun Yih
title Investigation into surface plasmon resonance based optical sensor
title_short Investigation into surface plasmon resonance based optical sensor
title_full Investigation into surface plasmon resonance based optical sensor
title_fullStr Investigation into surface plasmon resonance based optical sensor
title_full_unstemmed Investigation into surface plasmon resonance based optical sensor
title_sort investigation into surface plasmon resonance based optical sensor
publishDate 2019
url http://hdl.handle.net/10356/77659
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