Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs

An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor...

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Main Authors:	Koh, P.-F., Wang, P., Huang, J.-M., Loh, T.-P.
Other Authors:	School of Physical and Mathematical Sciences
Format:	Article
Language:	English
Published:	2015
Subjects:	DRNTU::Science::Chemistry
Online Access:	https://hdl.handle.net/10356/79354 http://hdl.handle.net/10220/25021
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-79354
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spelling	sg-ntu-dr.10356-793542023-02-28T19:29:49Z Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs Koh, P.-F. Wang, P. Huang, J.-M. Loh, T.-P. School of Physical and Mathematical Sciences DRNTU::Science::Chemistry An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor antagonist. Published version 2015-02-06T02:42:51Z 2019-12-06T13:23:16Z 2015-02-06T02:42:51Z 2019-12-06T13:23:16Z 2014 2014 Journal Article Koh, P.-F., Wang, P., Huang, J.-M., & Loh, T.-P. (2014). Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs. Chemical communications, 50(61), 8324-8327. 1359-7345 https://hdl.handle.net/10356/79354 http://hdl.handle.net/10220/25021 10.1039/C4CC02645D en Chemical communications © 2014 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	DRNTU::Science::Chemistry
spellingShingle	DRNTU::Science::Chemistry Koh, P.-F. Wang, P. Huang, J.-M. Loh, T.-P. Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs
description	An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor antagonist.
author2	School of Physical and Mathematical Sciences
author_facet	School of Physical and Mathematical Sciences Koh, P.-F. Wang, P. Huang, J.-M. Loh, T.-P.
format	Article
author	Koh, P.-F. Wang, P. Huang, J.-M. Loh, T.-P.
author_sort	Koh, P.-F.
title	Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs
title_short	Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs
title_full	Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs
title_fullStr	Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs
title_full_unstemmed	Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs
title_sort	biomass derived furfural-based facile synthesis of protected (2s)-phenyl-3-piperidone, a common intermediate for many drugs
publishDate	2015
url	https://hdl.handle.net/10356/79354 http://hdl.handle.net/10220/25021
_version_	1759856660525875200

Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs

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