Time-resolved botulinum neurotoxin A activity monitored using peptide-functionalized Au nanoparticle energy transfer sensors

• Main Authors: Wang, Yi, Liu, Xiaohu, Zhang, Jinling, Aili, Daniel, Liedberg, Bo
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: Energy Transfer; Gold; DRNTU::Engineering::Nanotechnology
• Online Access: https://hdl.handle.net/10356/79448; http://hdl.handle.net/10220/38490
• Institution: Nanyang Technological University

We report herein on the employment of synthetic peptide-functionalized gold nanoparticles (AuNPs) with various diameters as radiative quenchers for the time-resolved monitoring of botulinum A light chain (BoLcA) activity. The results demonstrate that larger AuNPs provide higher energy transfer effic...