LIR motif-containing hyperdisulfide β-ginkgotide is cytoprotective, adaptogenic, and scaffold-ready

• Main Authors: Dutta, Bamaprasad, Huang, Jiayi, To, Janet, Tam, James P.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Science::Biological sciences; Adaptogenic; Autophagy
• Online Access: https://hdl.handle.net/10356/79519; http://hdl.handle.net/10220/49718
• Institution: Nanyang Technological University

Grafting a bioactive peptide onto a disulfide-rich scaffold is a promising approach to improve its structure and metabolic stability. The ginkgo plant-derived β-ginkgotide β-gB1 is a highly unusual molecule: Small, hyperdisulfide, and found only in selected ancient plants. It also contains a conserv...