MicroRNA trimming in the nervous system

MicroRNAs are small, single-stranded RNAs about 22 nucleotides long which are involved in post-transcriptional regulation of mRNAs. MicroRNAs base-pair with regions on the 3’ UTR of target mRNAs which show partial complementarity to microRNA sequence and downregulate them by translational repression...

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Main Author: Lee, Li Ming
Other Authors: Evgeniy Makeyev
Format: Student Research Poster
Language:English
Published: 2013
Subjects:
Online Access:https://hdl.handle.net/10356/79541
http://hdl.handle.net/10220/9086
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-795412020-09-27T20:31:05Z MicroRNA trimming in the nervous system Lee, Li Ming Evgeniy Makeyev School of Biological Sciences MicroRNA Trimming MicroRNAs are small, single-stranded RNAs about 22 nucleotides long which are involved in post-transcriptional regulation of mRNAs. MicroRNAs base-pair with regions on the 3’ UTR of target mRNAs which show partial complementarity to microRNA sequence and downregulate them by translational repression or mRNA cleavage. To effect their biological functions, microRNAs require loading into the RNA-induced silencing complex by the Argonaute protein, the catalytic subunit of RISC. There are four proteins in the Argonaute protein family: Ago1, Ago2, Ago3 and Ago4. Ago2 mediates mRNA cleavage upon perfect sequence complementarity between mRNA and microRNA, whereas Ago1, 3 and 4 cause translational repression. MicroRNA-124 is a microRNA which regulates neuronal differentiation and is expressed in immature and terminally-differentiated neurons. It occurs as a population of 20-25 nucleotide-long microRNAs in the mouse brain. Upon maturation of the nervous system, the miR-124 population slowly changes from 22-mer as the most abundant form to 21-mer as the most abundant form, a process called microRNA trimming. [1st Award] 2013-02-01T02:35:33Z 2019-12-06T13:27:52Z 2013-02-01T02:35:33Z 2019-12-06T13:27:52Z 2011 2011 Student Research Poster Lee, L. M. (2011, March). MicroRNA trimming in the nervous system. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/79541 http://hdl.handle.net/10220/9086 en © 2011 The Author(s). application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic MicroRNA
Trimming
spellingShingle MicroRNA
Trimming
Lee, Li Ming
MicroRNA trimming in the nervous system
description MicroRNAs are small, single-stranded RNAs about 22 nucleotides long which are involved in post-transcriptional regulation of mRNAs. MicroRNAs base-pair with regions on the 3’ UTR of target mRNAs which show partial complementarity to microRNA sequence and downregulate them by translational repression or mRNA cleavage. To effect their biological functions, microRNAs require loading into the RNA-induced silencing complex by the Argonaute protein, the catalytic subunit of RISC. There are four proteins in the Argonaute protein family: Ago1, Ago2, Ago3 and Ago4. Ago2 mediates mRNA cleavage upon perfect sequence complementarity between mRNA and microRNA, whereas Ago1, 3 and 4 cause translational repression. MicroRNA-124 is a microRNA which regulates neuronal differentiation and is expressed in immature and terminally-differentiated neurons. It occurs as a population of 20-25 nucleotide-long microRNAs in the mouse brain. Upon maturation of the nervous system, the miR-124 population slowly changes from 22-mer as the most abundant form to 21-mer as the most abundant form, a process called microRNA trimming. [1st Award]
author2 Evgeniy Makeyev
author_facet Evgeniy Makeyev
Lee, Li Ming
format Student Research Poster
author Lee, Li Ming
author_sort Lee, Li Ming
title MicroRNA trimming in the nervous system
title_short MicroRNA trimming in the nervous system
title_full MicroRNA trimming in the nervous system
title_fullStr MicroRNA trimming in the nervous system
title_full_unstemmed MicroRNA trimming in the nervous system
title_sort microrna trimming in the nervous system
publishDate 2013
url https://hdl.handle.net/10356/79541
http://hdl.handle.net/10220/9086
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