Nanoporous carbon as a sensing platform for DNA detection : the use of impedance spectroscopy for hairpin-DNA based assay

Nanoporous carbon as a sensing platform for DNA detection : the use of impedance spectroscopy for hairpin-DNA based assay

Nanoporous carbons represent well defined materials with large surface area, defined porosity, high electrical conductivity and fast heterogeneous electron transfer rates. These materials are seldom used for sensing and even more rarely for biosensing. We for the first time show the application of n...

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Main Authors: Poh, Hwee Ling, Bonanni, Alessandra, Pumera, Martin
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Subjects:
DRNTU::Science::Chemistry::Biochemistry
Online Access:https://hdl.handle.net/10356/79628
http://hdl.handle.net/10220/10029
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-796282023-02-28T19:30:30Z Nanoporous carbon as a sensing platform for DNA detection : the use of impedance spectroscopy for hairpin-DNA based assay Poh, Hwee Ling Bonanni, Alessandra Pumera, Martin School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Biochemistry Nanoporous carbons represent well defined materials with large surface area, defined porosity, high electrical conductivity and fast heterogeneous electron transfer rates. These materials are seldom used for sensing and even more rarely for biosensing. We for the first time show the application of nanoporous carbon using electrochemical impedance spectroscopy technique to detect DNA hybridization and polymorphism. Our findings demonstrated the proof of concept of using nanoporous carbon in nucleic acid analysis, being able to detect the presence of a single nucleotide polymorphism. Accepted version 2013-05-30T08:43:37Z 2019-12-06T13:29:42Z 2013-05-30T08:43:37Z 2019-12-06T13:29:42Z 2012 2012 Journal Article Poh, H. L., Bonanni, A., & Pumera, M. (2012). Nanoporous carbon as a sensing platform for DNA detection: The use of impedance spectroscopy for hairpin-DNA based assay. RSC Advances, (2), 1021-1024. https://hdl.handle.net/10356/79628 http://hdl.handle.net/10220/10029 10.1039/C1RA00812A 165398 en RSC advances © 2012 The Royal Society of Chemistry. This paper was published in RSC Advances and is made available as an electronic reprint (preprint) with permission of The Royal Society of Chemistry. The paper can be found at the following official DOI: [http://dx.doi.org/10.1039/C1RA00812A]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 4 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Chemistry::Biochemistry
spellingShingle DRNTU::Science::Chemistry::Biochemistry
Poh, Hwee Ling
Bonanni, Alessandra
Pumera, Martin
Nanoporous carbon as a sensing platform for DNA detection : the use of impedance spectroscopy for hairpin-DNA based assay
description Nanoporous carbons represent well defined materials with large surface area, defined porosity, high electrical conductivity and fast heterogeneous electron transfer rates. These materials are seldom used for sensing and even more rarely for biosensing. We for the first time show the application of nanoporous carbon using electrochemical impedance spectroscopy technique to detect DNA hybridization and polymorphism. Our findings demonstrated the proof of concept of using nanoporous carbon in nucleic acid analysis, being able to detect the presence of a single nucleotide polymorphism.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Poh, Hwee Ling
Bonanni, Alessandra
Pumera, Martin
format Article
author Poh, Hwee Ling
Bonanni, Alessandra
Pumera, Martin
author_sort Poh, Hwee Ling
title Nanoporous carbon as a sensing platform for DNA detection : the use of impedance spectroscopy for hairpin-DNA based assay
title_short Nanoporous carbon as a sensing platform for DNA detection : the use of impedance spectroscopy for hairpin-DNA based assay
title_full Nanoporous carbon as a sensing platform for DNA detection : the use of impedance spectroscopy for hairpin-DNA based assay
title_fullStr Nanoporous carbon as a sensing platform for DNA detection : the use of impedance spectroscopy for hairpin-DNA based assay
title_full_unstemmed Nanoporous carbon as a sensing platform for DNA detection : the use of impedance spectroscopy for hairpin-DNA based assay
title_sort nanoporous carbon as a sensing platform for dna detection : the use of impedance spectroscopy for hairpin-dna based assay
publishDate 2013
url https://hdl.handle.net/10356/79628
http://hdl.handle.net/10220/10029
_version_ 1759854197416656896

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