Design and synthesis of multivalent neoglycoconjugates by click conjugations

Design and synthesis of multivalent neoglycoconjugates by click conjugations

A highly stereoselective BF3∙OEt2-promoted tandem hydroamination/glycosylation on glycal scaffolds has been developed to form propargyl 3-tosylamino-2,3-dideoxysugars in a one-pot manner. Subsequent construction of multivalent 3-tosylamino-2,3-dideoxyneoglycoconjugates with potential biochemical app...

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Main Authors: Ding, Feiqing, Ji, Li, William, Ronny, Chai, Hua, Liu, Xue-Wei
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Chemistry::Inorganic chemistry
Online Access:https://hdl.handle.net/10356/79683
http://hdl.handle.net/10220/20300
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-796832023-02-28T19:28:25Z Design and synthesis of multivalent neoglycoconjugates by click conjugations Ding, Feiqing Ji, Li William, Ronny Chai, Hua Liu, Xue-Wei School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Inorganic chemistry A highly stereoselective BF3∙OEt2-promoted tandem hydroamination/glycosylation on glycal scaffolds has been developed to form propargyl 3-tosylamino-2,3-dideoxysugars in a one-pot manner. Subsequent construction of multivalent 3-tosylamino-2,3-dideoxyneoglycoconjugates with potential biochemical applications was presented herein involving click conjugations as the key reaction step. The copper-catalyzed regioselective click reaction was tremendously accelerated with assistance of microwave irradiation. Published version 2014-08-15T06:15:50Z 2019-12-06T13:30:58Z 2014-08-15T06:15:50Z 2019-12-06T13:30:58Z 2014 2014 Journal Article Ding, F., Ji, L., William, R., Chai, H., & Liu, X.-W. (2014). Design and synthesis of multivalent neoglycoconjugates by click conjugations. Beilstein Journal of Organic Chemistry, 10, 1325-1332. 1860-5397 https://hdl.handle.net/10356/79683 http://hdl.handle.net/10220/20300 10.3762/bjoc.10.134 24991285 en Beilstein journal of organic chemistry © 2014 Ding et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc) application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Chemistry::Inorganic chemistry
spellingShingle DRNTU::Science::Chemistry::Inorganic chemistry
Ding, Feiqing
Ji, Li
William, Ronny
Chai, Hua
Liu, Xue-Wei
Design and synthesis of multivalent neoglycoconjugates by click conjugations
description A highly stereoselective BF3∙OEt2-promoted tandem hydroamination/glycosylation on glycal scaffolds has been developed to form propargyl 3-tosylamino-2,3-dideoxysugars in a one-pot manner. Subsequent construction of multivalent 3-tosylamino-2,3-dideoxyneoglycoconjugates with potential biochemical applications was presented herein involving click conjugations as the key reaction step. The copper-catalyzed regioselective click reaction was tremendously accelerated with assistance of microwave irradiation.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Ding, Feiqing
Ji, Li
William, Ronny
Chai, Hua
Liu, Xue-Wei
format Article
author Ding, Feiqing
Ji, Li
William, Ronny
Chai, Hua
Liu, Xue-Wei
author_sort Ding, Feiqing
title Design and synthesis of multivalent neoglycoconjugates by click conjugations
title_short Design and synthesis of multivalent neoglycoconjugates by click conjugations
title_full Design and synthesis of multivalent neoglycoconjugates by click conjugations
title_fullStr Design and synthesis of multivalent neoglycoconjugates by click conjugations
title_full_unstemmed Design and synthesis of multivalent neoglycoconjugates by click conjugations
title_sort design and synthesis of multivalent neoglycoconjugates by click conjugations
publishDate 2014
url https://hdl.handle.net/10356/79683
http://hdl.handle.net/10220/20300
_version_ 1759853638929350656

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