Fast depth-sensitive fluorescence measurements in turbid media using cone shell configuration
Depth-sensitive fluorescence spectroscopy in a two-layered epithelial tissue phantom was demonstrated using a cone shell configuration implemented by an axicon lens and a fiber assembly including five rings of collection fibers. Each collection fiber ring was located at a different radial dista...
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| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/79787 http://hdl.handle.net/10220/18796 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Depth-sensitive fluorescence spectroscopy in a
two-layered epithelial tissue phantom was demonstrated
using a cone shell configuration implemented by an axicon
lens and a fiber assembly including five rings of collection
fibers. Each collection fiber ring was located at a different
radial distance away from the center, for which fluorescence
measurements from all rings showed a larger range of sensitivities
to the top and bottom layers compared to the
previously reported cone shell configuration. Furthermore,
multiple fluorescence spectra corresponding to a range of
successive targeted depths can be obtained simultaneously,
which shortened data acquisition dramatically and eliminated
the mechanical moving components required for
depth-sensitive optical measurements in the previous setup.
This new setup therefore would be preferred in a clinical
setting. |
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