Structural basis of ligand recognition in 5-HT3 receptors

• Main Authors: Thompson, Andrew J., Villalgordo, Jose M., Lummis, Sarah C. R., Smit, August B., Kesters, Divya, Elk, René van, Brams, Marijke, Spurny, Radovan, Geitmann, Matthis, Guskov, Albert, Danielson, U. Helena, Ulens, Chris
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/79830; http://hdl.handle.net/10220/10973
• Institution: Nanyang Technological University

The 5-HT3 receptor is a pentameric serotonin-gated ion channel, which mediates rapid excitatory neurotransmission and is the target of a therapeutically important class of anti-emetic drugs, such as granisetron. We report crystal structures of a binding protein engineered to recognize the agonist se...