Single-Cell DNA-methylation analysis reveals epigenetic chimerism in preimplantation embryos

• Main Authors: Lorthongpanich, Chanchao, Cheow, Lih Feng, Balu, Sathish, Quake, Stephen R., Knowles, Barbara B., Burkholder, William F., Solter, Davor, Messerschmidt, Daniel M.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/79976; http://hdl.handle.net/10220/19858
• Institution: Nanyang Technological University

Epigenetic alterations are increasingly recognized as causes of human cancers and disease. These aberrations are likely to arise during genomic reprogramming in mammalian preimplantation embryos, when their epigenomes are most vulnerable. However, this process is only partially understood because of...