Absence of intestinal PPARγ aggravates acute infectious colitis in mice through a Lipocalin-2–dependent pathway

• Main Authors: Bunte, Ralph M., Kundu, Parag, Ling, Teo Wei, Korecka, Agata, Li, Yinghui, D'Arienzo, Rossana, Berger, Thorsten, Arulampalam, Velmurugesan, Chambon, Pierre, Mak, Tak Wah, Wahli, Walter, Pettersson, Sven
• Other Authors: Monack, Denise M.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::General
• Online Access: https://hdl.handle.net/10356/80010; http://hdl.handle.net/10220/18858
• Institution: Nanyang Technological University

To be able to colonize its host, invading Salmonella enterica serovar Typhimurium must disrupt and severely affect host-microbiome homeostasis. Here we report that S. Typhimurium induces acute infectious colitis by inhibiting peroxisome proliferator-activated receptor gamma (PPARγ) expression in int...