Notch transcriptional control of vascular smooth muscle regulatory gene expression and function

• Main Authors: Basu, S., Srinivasan, D. K., Yang, K., Raina, H., Banerjee, S., Zhang, R., Fisher, S. A., Proweller, A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2014
• Subjects: Medicine
• Online Access: https://hdl.handle.net/10356/80090; http://hdl.handle.net/10220/19277
• Institution: Nanyang Technological University

Notch receptors and ligands mediate heterotypic cell signaling that is required for normal vascular development. Dysregulation of select Notch receptors in mouse vascular smooth muscle (VSM) and in genetic human syndromes causes functional impairment in some regional circulations, the mechanistic ba...