Edging closer towards the goal of a dengue vaccine

Dengue is a growing global problem that urgently needs to be addressed [1]. Similarly to yellow fever, dengue is caused by viruses of the flaviviridae family and transmitted by Aedes mosquitoes, but unlike yellow fever for which we have had a vaccine for more than 80 years, the first dengue vaccine...

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Main Authors: Wilder-Smith, Annelies, Yoon, In-Kyu
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2016
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Online Access:https://hdl.handle.net/10356/80193
http://hdl.handle.net/10220/40434
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-801932020-11-01T05:16:02Z Edging closer towards the goal of a dengue vaccine Wilder-Smith, Annelies Yoon, In-Kyu Lee Kong Chian School of Medicine (LKCMedicine) Efficacy Non-structural proteins Risk-benefit ratio Dengue vaccines CYD-TDV Dengue is a growing global problem that urgently needs to be addressed [1]. Similarly to yellow fever, dengue is caused by viruses of the flaviviridae family and transmitted by Aedes mosquitoes, but unlike yellow fever for which we have had a vaccine for more than 80 years, the first dengue vaccine is only available now. Research and Development funding for dengue vaccine development has more than tripled in the past decades, much of which is driven by vaccine manufacturers [2]. We have a robust pipeline with several promising dengue vaccine candidates, all using different approaches [3]. The only vaccine to have completed Phase 3 trials is the CYD-TDV (a live attenuated recombinant chimeric tetravalent dengue vaccine developed by Sanofi Pasteur) sponsored by Sanofi Pasteur. Interestingly, the relatedness to other flaviviruses played a role in the development of CYD-TDV in which the 17D yellow fever virus backbone is used for chimerization with dengue viruses (DENVs). CYD-TDV is a formulation of four chimeras, each one engineered to express the envelope and pre-membrane proteins from one of the four serotypes of DENV [4]. Dengvaxia (CYD-TDV) was first licensed in Mexico in December 2015, and is meanwhile licensed in three other countries. Accepted version 2016-04-15T06:06:08Z 2019-12-06T13:42:39Z 2016-04-15T06:06:08Z 2019-12-06T13:42:39Z 2016 Journal Article Wilder-Smith, A., & Yoon, I.-K. (2016). Edging closer towards the goal of a dengue vaccine. Expert Review of Vaccines, 15(4), 433-435. 1476-0584 https://hdl.handle.net/10356/80193 http://hdl.handle.net/10220/40434 10.1586/14760584.2016.1154459 en Expert Review of Vaccines © 2016 Taylor & Francis. This is the author created version of a work that has been peer reviewed and accepted for publication by Expert Review of Vaccines, Taylor & Francis. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1586/14760584.2016.1154459]. 8 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Efficacy
Non-structural proteins
Risk-benefit ratio
Dengue vaccines
CYD-TDV
spellingShingle Efficacy
Non-structural proteins
Risk-benefit ratio
Dengue vaccines
CYD-TDV
Wilder-Smith, Annelies
Yoon, In-Kyu
Edging closer towards the goal of a dengue vaccine
description Dengue is a growing global problem that urgently needs to be addressed [1]. Similarly to yellow fever, dengue is caused by viruses of the flaviviridae family and transmitted by Aedes mosquitoes, but unlike yellow fever for which we have had a vaccine for more than 80 years, the first dengue vaccine is only available now. Research and Development funding for dengue vaccine development has more than tripled in the past decades, much of which is driven by vaccine manufacturers [2]. We have a robust pipeline with several promising dengue vaccine candidates, all using different approaches [3]. The only vaccine to have completed Phase 3 trials is the CYD-TDV (a live attenuated recombinant chimeric tetravalent dengue vaccine developed by Sanofi Pasteur) sponsored by Sanofi Pasteur. Interestingly, the relatedness to other flaviviruses played a role in the development of CYD-TDV in which the 17D yellow fever virus backbone is used for chimerization with dengue viruses (DENVs). CYD-TDV is a formulation of four chimeras, each one engineered to express the envelope and pre-membrane proteins from one of the four serotypes of DENV [4]. Dengvaxia (CYD-TDV) was first licensed in Mexico in December 2015, and is meanwhile licensed in three other countries.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Wilder-Smith, Annelies
Yoon, In-Kyu
format Article
author Wilder-Smith, Annelies
Yoon, In-Kyu
author_sort Wilder-Smith, Annelies
title Edging closer towards the goal of a dengue vaccine
title_short Edging closer towards the goal of a dengue vaccine
title_full Edging closer towards the goal of a dengue vaccine
title_fullStr Edging closer towards the goal of a dengue vaccine
title_full_unstemmed Edging closer towards the goal of a dengue vaccine
title_sort edging closer towards the goal of a dengue vaccine
publishDate 2016
url https://hdl.handle.net/10356/80193
http://hdl.handle.net/10220/40434
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