Non-coding functions of alternative pre-mRNA splicing in development

A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo alternative splicing to generate more than one mature product. By targeting the open reading frame region this process increases diversity of protein isoforms beyond the nominal coding capacity of the genome. However...

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Main Authors: Mockenhaupt, Stefan, Makeyev, Eugene V.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2016
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Online Access:https://hdl.handle.net/10356/80240
http://hdl.handle.net/10220/40451
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-802402023-02-28T17:00:07Z Non-coding functions of alternative pre-mRNA splicing in development Mockenhaupt, Stefan Makeyev, Eugene V. School of Biological Sciences Development Alternative pre-mRNA splicing mRNA stability Translational regulation mRNA localization A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo alternative splicing to generate more than one mature product. By targeting the open reading frame region this process increases diversity of protein isoforms beyond the nominal coding capacity of the genome. However, alternative splicing also frequently controls output levels and spatiotemporal features of cellular and organismal gene expression programs. Here we discuss how these non-coding functions of alternative splicing contribute to development through regulation of mRNA stability, translational efficiency and cellular localization. NMRC (Natl Medical Research Council, S’pore) Accepted version 2016-04-15T06:44:19Z 2019-12-06T13:45:38Z 2016-04-15T06:44:19Z 2019-12-06T13:45:38Z 2015 Journal Article Mockenhaupt, S., & Makeyev, E. V. (2015). Non-coding functions of alternative pre-mRNA splicing in development. Seminars in Cell & Developmental Biology, 47-48, 32-39. 1084-9521 https://hdl.handle.net/10356/80240 http://hdl.handle.net/10220/40451 10.1016/j.semcdb.2015.10.018 26493705 en Seminars in Cell & Developmental Biology © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). 27 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Development
Alternative pre-mRNA splicing
mRNA stability
Translational regulation
mRNA localization
spellingShingle Development
Alternative pre-mRNA splicing
mRNA stability
Translational regulation
mRNA localization
Mockenhaupt, Stefan
Makeyev, Eugene V.
Non-coding functions of alternative pre-mRNA splicing in development
description A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo alternative splicing to generate more than one mature product. By targeting the open reading frame region this process increases diversity of protein isoforms beyond the nominal coding capacity of the genome. However, alternative splicing also frequently controls output levels and spatiotemporal features of cellular and organismal gene expression programs. Here we discuss how these non-coding functions of alternative splicing contribute to development through regulation of mRNA stability, translational efficiency and cellular localization.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Mockenhaupt, Stefan
Makeyev, Eugene V.
format Article
author Mockenhaupt, Stefan
Makeyev, Eugene V.
author_sort Mockenhaupt, Stefan
title Non-coding functions of alternative pre-mRNA splicing in development
title_short Non-coding functions of alternative pre-mRNA splicing in development
title_full Non-coding functions of alternative pre-mRNA splicing in development
title_fullStr Non-coding functions of alternative pre-mRNA splicing in development
title_full_unstemmed Non-coding functions of alternative pre-mRNA splicing in development
title_sort non-coding functions of alternative pre-mrna splicing in development
publishDate 2016
url https://hdl.handle.net/10356/80240
http://hdl.handle.net/10220/40451
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