Structural and Functional Insights into the Evolution and Stress Adaptation of Type II Chaperonins

• Main Authors: Chaston, Jessica J., Smits, Callum, Aragão, David, Ahsan, Bilal, Sandin, Sara, Stock, Daniela, Wong, Andrew S. W., Molugu, Sudheer K., Molugu, Sanjay K., Bernal, Ricardo A., Stewart, Alastair G.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Biological Sciences
• Online Access: https://hdl.handle.net/10356/80266; http://hdl.handle.net/10220/40448
• Institution: Nanyang Technological University

Chaperonins are essential biological complexes assisting protein folding in all kingdoms of life. Whereas homooligomeric bacterial GroEL binds hydrophobic substrates non-specifically, the heterooligomeric eukaryotic CCT binds specifically to distinct classes of substrates. Sulfolobales, which surviv...