Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons
Optogenetics provides powerful means for precise control of neuronal activity; however, the requirement of transgenesis and the incapability to extend the neuron excitation window into the deep-tissue-penetrating near-infrared (NIR) region partially limit its application. We herein report a potentia...
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sg-ntu-dr.10356-802772023-12-29T06:53:46Z Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons Lyu, Yan Xie, Chen Chechetka, Svetlana A. Miyako, Eijiro Pu, Kanyi School of Chemical and Biomedical Engineering Semiconducting polymers Activation of neurons Optogenetics provides powerful means for precise control of neuronal activity; however, the requirement of transgenesis and the incapability to extend the neuron excitation window into the deep-tissue-penetrating near-infrared (NIR) region partially limit its application. We herein report a potential alternative approach to optogenetics using semiconducting polymer nanobioconjugates (SPNsbc) as the photothermal nanomodulator to control the thermosensitive ion channels in neurons. SPNsbc are designed to efficiently absorb the NIR light at 808 nm and have a photothermal conversion efficiency higher than that of gold nanorods. By virtue of the fast heating capability in conjunction with the precise targeting to the thermosensitive ion channel, SPNsbc can specifically and rapidly activate the intracellular Ca2+ influx of neuronal cells in a reversible and safe manner. Our study provides an organic nanoparticle based strategy that eliminates the need for genetic transfection to remotely regulate cellular machinery. MOE (Min. of Education, S’pore) Accepted version 2017-02-27T06:52:58Z 2019-12-06T13:46:20Z 2017-02-27T06:52:58Z 2019-12-06T13:46:20Z 2016 2016 Journal Article Lyu, Y., Xie, C., Chechetka, S. A., Miyako, E., & Pu, K. (2016). Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons. Journal of the American Chemical Society, 138(29), 9049–9052. 0002-7863 https://hdl.handle.net/10356/80277 http://hdl.handle.net/10220/42130 10.1021/jacs.6b05192 196114 en Journal of the American Chemical Society © 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of the American Chemical Society, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/jacs.6b05192]. 6 p. application/pdf |
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Semiconducting polymers Activation of neurons Lyu, Yan Xie, Chen Chechetka, Svetlana A. Miyako, Eijiro Pu, Kanyi Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons |
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Optogenetics provides powerful means for precise control of neuronal activity; however, the requirement of transgenesis and the incapability to extend the neuron excitation window into the deep-tissue-penetrating near-infrared (NIR) region partially limit its application. We herein report a potential alternative approach to optogenetics using semiconducting polymer nanobioconjugates (SPNsbc) as the photothermal nanomodulator to control the thermosensitive ion channels in neurons. SPNsbc are designed to efficiently absorb the NIR light at 808 nm and have a photothermal conversion efficiency higher than that of gold nanorods. By virtue of the fast heating capability in conjunction with the precise targeting to the thermosensitive ion channel, SPNsbc can specifically and rapidly activate the intracellular Ca2+ influx of neuronal cells in a reversible and safe manner. Our study provides an organic nanoparticle based strategy that eliminates the need for genetic transfection to remotely regulate cellular machinery. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Lyu, Yan Xie, Chen Chechetka, Svetlana A. Miyako, Eijiro Pu, Kanyi |
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Article |
author |
Lyu, Yan Xie, Chen Chechetka, Svetlana A. Miyako, Eijiro Pu, Kanyi |
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Lyu, Yan |
title |
Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons |
title_short |
Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons |
title_full |
Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons |
title_fullStr |
Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons |
title_full_unstemmed |
Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons |
title_sort |
semiconducting polymer nanobioconjugates for targeted photothermal activation of neurons |
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2017 |
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https://hdl.handle.net/10356/80277 http://hdl.handle.net/10220/42130 |
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1787136814754037760 |