Low antibody titers five years after vaccination with the CYD-TDV dengue vaccine in both pre-immune and naïve vaccinees

• Main Authors: Velumani, Sumathy, Toh, Ying Xiu, Balasingam, Shobana, Archuleta, Sophia, Leo, Yee Sin, Gan, Victor C., Thein, Tun Linn, Wilder-Smith, Annelies, Fink, Katja
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Dengue; Vaccine; Memory B cells; Antibodies; Immune memory; Long-term
• Online Access: https://hdl.handle.net/10356/80285; http://hdl.handle.net/10220/40441
• Institution: Nanyang Technological University

Globally, dengue virus (DENV) is one of the most widespread vector-borne viruses. Dengue disease affects populations in endemic areas and, increasingly, tourists who travel to these countries, but there is currently no approved vaccine for dengue. A phase 3 efficacy trial with Sanofi-Pasteur's...