Optimising probe holder design for sentinel lymph node imaging using clinical photoacoustic system with Monte Carlo simulation

Photoacoustic tomography is a hybrid imaging modality that combines optical and ultrasound imaging. It is rapidly gaining attention in the field of medical imaging. The challenge is to translate it into a clinical setup. In this work, we report the development of a handheld clinical photoacoustic im...

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Main Authors: Sivasubramanian, Kathyayini, Periyasamy, Vijitha, Wen, Kew Kok, Pramanik, Manojit
Other Authors: School of Chemical and Biomedical Engineering
Format: Conference or Workshop Item
Language:English
Published: 2017
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Online Access:https://hdl.handle.net/10356/80359
http://hdl.handle.net/10220/42153
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-803592023-12-29T06:44:13Z Optimising probe holder design for sentinel lymph node imaging using clinical photoacoustic system with Monte Carlo simulation Sivasubramanian, Kathyayini Periyasamy, Vijitha Wen, Kew Kok Pramanik, Manojit School of Chemical and Biomedical Engineering Proceeding of SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017 Handheld probe Photoacoustic tomography Photoacoustic tomography is a hybrid imaging modality that combines optical and ultrasound imaging. It is rapidly gaining attention in the field of medical imaging. The challenge is to translate it into a clinical setup. In this work, we report the development of a handheld clinical photoacoustic imaging system. A clinical ultrasound imaging system is modified to integrate photoacoustic imaging with the ultrasound imaging. Hence, light delivery has been integrated with the ultrasound probe. The angle of light delivery is optimized in this work with respect to the depth of imaging. Optimization was performed based on Monte Carlo simulation for light transport in tissues. Based on the simulation results, the probe holders were fabricated using 3D printing. Similar results were obtained experimentally using phantoms. Phantoms were developed to mimic sentinel lymph node imaging scenario. Also, in vivo sentinel lymph node imaging was done using the same system with contrast agent methylene blue up to a depth of 1.5 cm. The results validate that one can use Monte Carlo simulation as a tool to optimize the probe holder design depending on the imaging needs. This eliminates a trial and error approach generally used for designing a probe holder. MOE (Min. of Education, S’pore) Published version 2017-03-06T03:27:37Z 2019-12-06T13:47:56Z 2017-03-06T03:27:37Z 2019-12-06T13:47:56Z 2017-03-01 2017 Conference Paper Sivasubramanian, K., Periyasamy, V., Wen, K. K., & Pramanik, M. (2017). Optimising probe holder design for sentinel lymph node imaging using clinical photoacoustic system with Monte Carlo simulation. Proceeding of SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100645N-. https://hdl.handle.net/10356/80359 http://hdl.handle.net/10220/42153 10.1117/12.2250478 196225 en © 2017 Society of Photo-optical Instrumentation Engineers (SPIE). This paper was published in Proceeding of SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017 and is made available as an electronic reprint (preprint) with permission of SPIE. The published version is available at: http://dx.doi.org/10.1117/12.2250478. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 7 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Handheld probe
Photoacoustic tomography
spellingShingle Handheld probe
Photoacoustic tomography
Sivasubramanian, Kathyayini
Periyasamy, Vijitha
Wen, Kew Kok
Pramanik, Manojit
Optimising probe holder design for sentinel lymph node imaging using clinical photoacoustic system with Monte Carlo simulation
description Photoacoustic tomography is a hybrid imaging modality that combines optical and ultrasound imaging. It is rapidly gaining attention in the field of medical imaging. The challenge is to translate it into a clinical setup. In this work, we report the development of a handheld clinical photoacoustic imaging system. A clinical ultrasound imaging system is modified to integrate photoacoustic imaging with the ultrasound imaging. Hence, light delivery has been integrated with the ultrasound probe. The angle of light delivery is optimized in this work with respect to the depth of imaging. Optimization was performed based on Monte Carlo simulation for light transport in tissues. Based on the simulation results, the probe holders were fabricated using 3D printing. Similar results were obtained experimentally using phantoms. Phantoms were developed to mimic sentinel lymph node imaging scenario. Also, in vivo sentinel lymph node imaging was done using the same system with contrast agent methylene blue up to a depth of 1.5 cm. The results validate that one can use Monte Carlo simulation as a tool to optimize the probe holder design depending on the imaging needs. This eliminates a trial and error approach generally used for designing a probe holder.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Sivasubramanian, Kathyayini
Periyasamy, Vijitha
Wen, Kew Kok
Pramanik, Manojit
format Conference or Workshop Item
author Sivasubramanian, Kathyayini
Periyasamy, Vijitha
Wen, Kew Kok
Pramanik, Manojit
author_sort Sivasubramanian, Kathyayini
title Optimising probe holder design for sentinel lymph node imaging using clinical photoacoustic system with Monte Carlo simulation
title_short Optimising probe holder design for sentinel lymph node imaging using clinical photoacoustic system with Monte Carlo simulation
title_full Optimising probe holder design for sentinel lymph node imaging using clinical photoacoustic system with Monte Carlo simulation
title_fullStr Optimising probe holder design for sentinel lymph node imaging using clinical photoacoustic system with Monte Carlo simulation
title_full_unstemmed Optimising probe holder design for sentinel lymph node imaging using clinical photoacoustic system with Monte Carlo simulation
title_sort optimising probe holder design for sentinel lymph node imaging using clinical photoacoustic system with monte carlo simulation
publishDate 2017
url https://hdl.handle.net/10356/80359
http://hdl.handle.net/10220/42153
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