Binary toxin subunits of Lysinibacillus sphaericus are monomeric and form heterodimers after in vitro activation

• Main Authors: Surya, Wahyu, Chooduang, Sivadatch, Choong, Yeu Khai, Torres, Jaume, Boonserm, Panadda
• Other Authors: Jurat-Fuentes, Juan Luis
• Format: Article
• Language: English
• Published: 2018
• Subjects: Lysinibacillus Sphaericus; Binary Toxin; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/80455; http://hdl.handle.net/10220/46527
• Institution: Nanyang Technological University

The binary toxin from Lysinibacillus sphaericus has been successfully used for controlling mosquito-transmitted diseases. An activation step shortens both subunits BinA and BinB before their interaction with membranes and internalization in midgut cells, but the precise role of this activation step...