Control of plasma membrane lipid homeostasis by the extended synaptotagmins

• Main Authors: Saheki, Yasunori, Bian, Xin, Schauder, Curtis M., Sawaki, Yujin, Surma, Michal A., Klose, Christian, Pincet, Frederic, Reinisch, Karin M., De Camilli, Pietro
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Calcium signalling; Endoplasmic reticulum; Lipid signalling; Membrane trafficking
• Online Access: https://hdl.handle.net/10356/80526; http://hdl.handle.net/10220/40524
• Institution: Nanyang Technological University

Acute metabolic changes in plasma membrane (PM) lipids, such as those mediating signalling reactions, are rapidly compensated by homeostatic responses whose molecular basis is poorly understood. Here we show that the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function...