Control of plasma membrane lipid homeostasis by the extended synaptotagmins

• المؤلفون الرئيسيون: Saheki, Yasunori, Bian, Xin, Schauder, Curtis M., Sawaki, Yujin, Surma, Michal A., Klose, Christian, Pincet, Frederic, Reinisch, Karin M., De Camilli, Pietro
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: Calcium signalling; Endoplasmic reticulum; Lipid signalling; Membrane trafficking
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/80526; http://hdl.handle.net/10220/40524
• المؤسسة: Nanyang Technological University

Acute metabolic changes in plasma membrane (PM) lipids, such as those mediating signalling reactions, are rapidly compensated by homeostatic responses whose molecular basis is poorly understood. Here we show that the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function...