High-throughput screening of PLGA thin films utilizing hydrophobic fluorescent dyes for hydrophobic drug compounds

• Main Authors: Steele, Terry W. J., Huang, Charlotte L., Kumar, Saranya, Widjaja, Effendi, Boey, Freddy Yin Chiang, Loo, Joachim Say Chye, Venkatraman, Subbu S.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: PLGA; Paclitaxel
• Online Access: https://hdl.handle.net/10356/80640; http://hdl.handle.net/10220/42180
• Institution: Nanyang Technological University

Hydrophobic, antirestenotic drugs such as paclitaxel (PCTX) and rapamycin are often incorporated into thin film coatings for local delivery using implantable medical devices and polymers such as drug-eluting stents and balloons. Selecting the optimum coating formulation through screening the release...