Clarifying the neural basis of obsessive compulsive disorder : a combined structural and functional magnetic resonance imaging study
Obsessive-compulsive disorder (OCD) is a debilitating disorder with limited treatment efficacies. This could partly be attributed to inadequate knowledge of the neurobiological basis of the disorder. Even though OCD has a prevalence rate of 3% in Singapore, research in OCD is relatively lacking comp...
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sg-ntu-dr.10356-806762020-07-01T01:43:10Z Clarifying the neural basis of obsessive compulsive disorder : a combined structural and functional magnetic resonance imaging study Eng, Goi Khia Chen Shen-Hsing Annabel School of Social Sciences DRNTU::Social sciences::Psychology Obsessive-compulsive disorder (OCD) is a debilitating disorder with limited treatment efficacies. This could partly be attributed to inadequate knowledge of the neurobiological basis of the disorder. Even though OCD has a prevalence rate of 3% in Singapore, research in OCD is relatively lacking compared to other psychiatric conditions. Existing neuroimaging literature in OCD have commonly reported abnormalities within the fronto-striatal regions, and some studies also indicated the involvement of the cerebellum in the disorder. However, exact contributions of the cerebellum in OCD pathophysiology have been unexplored. This thesis aims to clarify the neural basis and examine aberrant neural activity involved in OCD pathophysiology. Four studies are presented in this thesis. Study 1 presents a meta-analysis to synthesize existing findings of differences in structural grey matter and executive-function task-related activations between OCD samples and controls. Results indicated group differences in frontal-thalamic and cerebellar grey matter, and task-related activations in the cingulate, parietal and caudate regions. These findings suggest probable involvement of regions beyond the cortico-striatal-thalamo-cortical (CSTC) circuitry in OCD pathophysiology. Findings from Study 1 set the stage for subsequent neural investigations... Doctor of Philosophy 2019-05-07T01:00:34Z 2019-12-06T13:54:30Z 2019-05-07T01:00:34Z 2019-12-06T13:54:30Z 2019 Thesis Eng, G. K. (2019). Clarifying the neural basis of obsessive compulsive disorder : a combined structural and functional magnetic resonance imaging study. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/80676 http://hdl.handle.net/10220/48108 10.32657/10220/48108 en 366 p. application/pdf |
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DRNTU::Social sciences::Psychology Eng, Goi Khia Clarifying the neural basis of obsessive compulsive disorder : a combined structural and functional magnetic resonance imaging study |
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Obsessive-compulsive disorder (OCD) is a debilitating disorder with limited treatment efficacies. This could partly be attributed to inadequate knowledge of the neurobiological basis of the disorder. Even though OCD has a prevalence rate of 3% in Singapore, research in OCD is relatively lacking compared to other psychiatric conditions. Existing neuroimaging literature in OCD have commonly reported abnormalities within the fronto-striatal regions, and some studies also indicated the involvement of the cerebellum in the disorder. However, exact contributions of the cerebellum in OCD pathophysiology have been unexplored.
This thesis aims to clarify the neural basis and examine aberrant neural activity
involved in OCD pathophysiology. Four studies are presented in this thesis. Study 1 presents
a meta-analysis to synthesize existing findings of differences in structural grey matter and
executive-function task-related activations between OCD samples and controls. Results
indicated group differences in frontal-thalamic and cerebellar grey matter, and task-related
activations in the cingulate, parietal and caudate regions. These findings suggest probable
involvement of regions beyond the cortico-striatal-thalamo-cortical (CSTC) circuitry in OCD
pathophysiology. Findings from Study 1 set the stage for subsequent neural investigations... |
author2 |
Chen Shen-Hsing Annabel |
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Chen Shen-Hsing Annabel Eng, Goi Khia |
format |
Theses and Dissertations |
author |
Eng, Goi Khia |
author_sort |
Eng, Goi Khia |
title |
Clarifying the neural basis of obsessive compulsive disorder : a combined structural and functional magnetic resonance imaging study |
title_short |
Clarifying the neural basis of obsessive compulsive disorder : a combined structural and functional magnetic resonance imaging study |
title_full |
Clarifying the neural basis of obsessive compulsive disorder : a combined structural and functional magnetic resonance imaging study |
title_fullStr |
Clarifying the neural basis of obsessive compulsive disorder : a combined structural and functional magnetic resonance imaging study |
title_full_unstemmed |
Clarifying the neural basis of obsessive compulsive disorder : a combined structural and functional magnetic resonance imaging study |
title_sort |
clarifying the neural basis of obsessive compulsive disorder : a combined structural and functional magnetic resonance imaging study |
publishDate |
2019 |
url |
https://hdl.handle.net/10356/80676 http://hdl.handle.net/10220/48108 |
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1681058765823016960 |