Functionalization of the Polymeric Surface with Bioceramic Nanoparticles via a Novel, Nonthermal Dip Coating Method

The only nonthermal method of depositing a bioceramic-based coating on polymeric substrates is by incubation in liquid, e.g., simulated body fluid to form an apatite-like layer. The drawbacks of this method include the long processing time, the production of low scratch resistant coating, and an end...

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Main Authors: Riau, Andri K., Mondal, Debasish, Setiawan, Melina, Palaniappan, Alagappan, Yam, Gary H. F., Liedberg, Bo, Venkatraman, Subbu S., Mehta, Jodhbir Singh
Other Authors: School of Materials Science & Engineering
Format: Article
Language:English
Published: 2017
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Online Access:https://hdl.handle.net/10356/80680
http://hdl.handle.net/10220/43428
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-806802023-07-14T15:45:27Z Functionalization of the Polymeric Surface with Bioceramic Nanoparticles via a Novel, Nonthermal Dip Coating Method Riau, Andri K. Mondal, Debasish Setiawan, Melina Palaniappan, Alagappan Yam, Gary H. F. Liedberg, Bo Venkatraman, Subbu S. Mehta, Jodhbir Singh School of Materials Science & Engineering Centre for Biomimetic Sensor Science Bioceramic Nanoparticles The only nonthermal method of depositing a bioceramic-based coating on polymeric substrates is by incubation in liquid, e.g., simulated body fluid to form an apatite-like layer. The drawbacks of this method include the long processing time, the production of low scratch resistant coating, and an end product that does not resemble the intended bioceramic composition. Techniques, such as plasma spraying and magnetron sputtering, involving high processing temperature are unsuitable for polymers, e.g., PMMA. Here, we introduce a nonthermal coating method to immobilize hydroxyapatite (HAp) and TiO2 nanoparticles on PMMA via a simple and fast dip coating method. Cavities that formed on the PMMA, induced by chloroform, appeared to trap the nanoparticles which accumulated to form layers of bioceramic coating only after 60 s. The resulting coating was hydrophilic and highly resistant to delamination. In the context of our research and to address the current clinical need, we demonstrate that the HAp-coated PMMA, which is intended to be used as a visual optic of a corneal prosthetic device, improves its bonding and biointegration with collagen, the main component of a corneal stroma. The HAp-coated PMMA resulted in better adhesion with the collagen than untreated PMMA in artificial tear fluid over 28 days. Human corneal stromal fibroblasts showed better attachment, viability, and proliferation rate on the HAp-coated PMMA than on untreated PMMA. This coating method is an innovative solution to immobilize various bioceramic nanoparticles on polymers and may be used in other biomedical implants. NMRC (Natl Medical Research Council, S’pore) Accepted version 2017-07-25T04:10:11Z 2019-12-06T13:54:35Z 2017-07-25T04:10:11Z 2019-12-06T13:54:35Z 2016 Journal Article Riau, A. K., Mondal, D., Setiawan, M., Palaniappan, A., Yam, G. H. F., Liedberg, B., et al. (2016). Functionalization of the Polymeric Surface with Bioceramic Nanoparticles via a Novel, Nonthermal Dip Coating Method. ACS Applied Materials & Interfaces, 8(51), 35565-35577. 1944-8244 https://hdl.handle.net/10356/80680 http://hdl.handle.net/10220/43428 10.1021/acsami.6b12371 en ACS Applied Materials & Interfaces © 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by ACS Applied Materials & Interfaces, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acsami.6b12371]. 42 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Bioceramic
Nanoparticles
spellingShingle Bioceramic
Nanoparticles
Riau, Andri K.
Mondal, Debasish
Setiawan, Melina
Palaniappan, Alagappan
Yam, Gary H. F.
Liedberg, Bo
Venkatraman, Subbu S.
Mehta, Jodhbir Singh
Functionalization of the Polymeric Surface with Bioceramic Nanoparticles via a Novel, Nonthermal Dip Coating Method
description The only nonthermal method of depositing a bioceramic-based coating on polymeric substrates is by incubation in liquid, e.g., simulated body fluid to form an apatite-like layer. The drawbacks of this method include the long processing time, the production of low scratch resistant coating, and an end product that does not resemble the intended bioceramic composition. Techniques, such as plasma spraying and magnetron sputtering, involving high processing temperature are unsuitable for polymers, e.g., PMMA. Here, we introduce a nonthermal coating method to immobilize hydroxyapatite (HAp) and TiO2 nanoparticles on PMMA via a simple and fast dip coating method. Cavities that formed on the PMMA, induced by chloroform, appeared to trap the nanoparticles which accumulated to form layers of bioceramic coating only after 60 s. The resulting coating was hydrophilic and highly resistant to delamination. In the context of our research and to address the current clinical need, we demonstrate that the HAp-coated PMMA, which is intended to be used as a visual optic of a corneal prosthetic device, improves its bonding and biointegration with collagen, the main component of a corneal stroma. The HAp-coated PMMA resulted in better adhesion with the collagen than untreated PMMA in artificial tear fluid over 28 days. Human corneal stromal fibroblasts showed better attachment, viability, and proliferation rate on the HAp-coated PMMA than on untreated PMMA. This coating method is an innovative solution to immobilize various bioceramic nanoparticles on polymers and may be used in other biomedical implants.
author2 School of Materials Science & Engineering
author_facet School of Materials Science & Engineering
Riau, Andri K.
Mondal, Debasish
Setiawan, Melina
Palaniappan, Alagappan
Yam, Gary H. F.
Liedberg, Bo
Venkatraman, Subbu S.
Mehta, Jodhbir Singh
format Article
author Riau, Andri K.
Mondal, Debasish
Setiawan, Melina
Palaniappan, Alagappan
Yam, Gary H. F.
Liedberg, Bo
Venkatraman, Subbu S.
Mehta, Jodhbir Singh
author_sort Riau, Andri K.
title Functionalization of the Polymeric Surface with Bioceramic Nanoparticles via a Novel, Nonthermal Dip Coating Method
title_short Functionalization of the Polymeric Surface with Bioceramic Nanoparticles via a Novel, Nonthermal Dip Coating Method
title_full Functionalization of the Polymeric Surface with Bioceramic Nanoparticles via a Novel, Nonthermal Dip Coating Method
title_fullStr Functionalization of the Polymeric Surface with Bioceramic Nanoparticles via a Novel, Nonthermal Dip Coating Method
title_full_unstemmed Functionalization of the Polymeric Surface with Bioceramic Nanoparticles via a Novel, Nonthermal Dip Coating Method
title_sort functionalization of the polymeric surface with bioceramic nanoparticles via a novel, nonthermal dip coating method
publishDate 2017
url https://hdl.handle.net/10356/80680
http://hdl.handle.net/10220/43428
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