Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

• Main Authors: Chattopadhyay, Anasuya, O’Connor, Cornelius J., Zhang, Fengzhi, Galvagnion, Celine, Galloway, Warren R. J. D., Tan, Yaw Sing, Stokes, Jamie E., Rahman, Taufiq, Verma, Chandra, Spring, David R., Itzhaki, Laura S.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: DNA Damage; DRNTU::Science::Biological sciences; Cell Cycle Protein
• Online Access: https://hdl.handle.net/10356/80807; http://hdl.handle.net/10220/46601
• Institution: Nanyang Technological University

Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. Elevated gankyrin levels are linked to aberrant cellular events including enhanced degradation of tumour suppressor protein p53, and inhibition of gankyrin activity has therefo...