N‑Heterocyclic Carbene-Catalyzed Radical Reactions for Highly Enantioselective β‑Hydroxylation of Enals

N‑Heterocyclic Carbene-Catalyzed Radical Reactions for Highly Enantioselective β‑Hydroxylation of Enals

An N-heterocyclic carbene-catalyzed β-hydroxylation of enals is developed. The reaction goes through a pathway involving multiple radical intermediates, as supported by experimental observations. This oxidative single-electron-transfer reaction allows for highly enantioselective access to β-hydroxyl...

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Bibliographic Details
Main Authors: Zhang, Yuexia, Du, Yu, Huang, Zhijian, Xu, Jianfeng, Wu, Xingxing, Wang, Yuhuang, Wang, Ming, Yang, Song, Webster, Richard D., Chi, Robin Yonggui
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2016
Subjects:
Chemistry and Biological Chemistry
Online Access:https://hdl.handle.net/10356/80814
http://hdl.handle.net/10220/40626
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Institution: Nanyang Technological University
Language: English
Description
Summary:An N-heterocyclic carbene-catalyzed β-hydroxylation of enals is developed. The reaction goes through a pathway involving multiple radical intermediates, as supported by experimental observations. This oxidative single-electron-transfer reaction allows for highly enantioselective access to β-hydroxyl esters that are widely found in natural products and bioactive molecules.

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