Dengue Serotype Cross-Reactive, Anti-E Protein Antibodies Confound Specific Immune Memory for 1 Year after Infection

• Main Authors: Toh, Ying Xiu, Gan, Victor, Balakrishnan, Thavamalar, Zuest, Roland, Poidinger, Michael, Wilson, Solomonraj, Appanna, Ramapraba, Thein, Tun Linn, Ong, Adrian Kheng-Yeow, Ng, Lee Ching, Leo, Yee Sin, Fink, Katja
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Subjects: B cells; Dengue; Viral infection; Antibodies; Plasmablasts; Longitudinal studies; Cross-reactive; Vaccines
• Online Access: https://hdl.handle.net/10356/80938; http://hdl.handle.net/10220/38982
• Institution: Nanyang Technological University

Dengue virus has four serotypes and is endemic globally in tropical countries. Neither a specific treatment nor an approved vaccine is available, and correlates of protection are not established. The standard neutralization assay cannot differentiate between serotype-specific and serotype cross-reac...