Genome-wide mapping of Hif-1α binding sites in zebrafish

• Main Authors: Greenald, David, Jeyakani, Justin, Pelster, Bernd, Sealy, Ian, Mathavan, Sinnakaruppan, van Eeden, Fredericus J.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Subjects: Hif-1α; ChIP-seq; Microarray; Hypoxia Response Element; Hypoxia; Zebrafish; Von Hippel-Lindau
• Online Access: https://hdl.handle.net/10356/80942; http://hdl.handle.net/10220/39022
• Institution: Nanyang Technological University

Background: Hypoxia Inducible Factor (HIF) regulates a cascade of transcriptional events in response to decreased oxygenation, acting from the cellular to the physiological level. This response is evolutionarily conserved, allowing the use of zebrafish (Danio rerio) as a model for studying the hypo...