Microarray profiling shows distinct differences between primary tumors and commonly used preclinical models in hepatocellular carcinoma

• Main Authors: Wang, Weining, Iyer, N. Gopalakrishna, Tay, Hsien Ts’ung, Wu, Yonghui, Lim, Tony K. H., Zheng, Lin, Song, In Chin, Kwoh, Chee Keong, Huynh, Hung, Tan, Patrick O. B., Chow, Pierce K. H.
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: Orthotopic; Xenograft; HepG2 cell line; Hepatocellular carcinoma; Ectopic
• Online Access: https://hdl.handle.net/10356/80966; http://hdl.handle.net/10220/38996
• Institution: Nanyang Technological University

Background: Despite advances in therapeutics, outcomes for hepatocellular carcinoma (HCC) remain poor and there is an urgent need for efficacious systemic therapy. Unfortunately, drugs that are successful in preclinical studies often fail in the clinical setting, and we hypothesize that this is due...