Microarray profiling shows distinct differences between primary tumors and commonly used preclinical models in hepatocellular carcinoma

• المؤلفون الرئيسيون: Wang, Weining, Iyer, N. Gopalakrishna, Tay, Hsien Ts’ung, Wu, Yonghui, Lim, Tony K. H., Zheng, Lin, Song, In Chin, Kwoh, Chee Keong, Huynh, Hung, Tan, Patrick O. B., Chow, Pierce K. H.
• مؤلفون آخرون: School of Computer Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: Orthotopic; Xenograft; HepG2 cell line; Hepatocellular carcinoma; Ectopic
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/80966; http://hdl.handle.net/10220/38996

Background: Despite advances in therapeutics, outcomes for hepatocellular carcinoma (HCC) remain poor and there is an urgent need for efficacious systemic therapy. Unfortunately, drugs that are successful in preclinical studies often fail in the clinical setting, and we hypothesize that this is due...