Genetics of Type 2 Diabetes and Clinical Utility

A large proportion of heritability of type 2 diabetes (T2D) has been attributed to inherent genetics. Recent genetic studies, especially genome-wide association studies (GWAS), have identified a multitude of variants associated with T2D. It is thus reasonable to question if these findings may be uti...

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Main Authors: Dorajoo, Rajkumar, Liu, Jianjun, Boehm, Bernhard Otto
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2015
Subjects:
Online Access:https://hdl.handle.net/10356/81003
http://hdl.handle.net/10220/39027
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-810032022-02-16T16:30:08Z Genetics of Type 2 Diabetes and Clinical Utility Dorajoo, Rajkumar Liu, Jianjun Boehm, Bernhard Otto Lee Kong Chian School of Medicine (LKCMedicine) Type 2 diabetes Genetics Clinical utility A large proportion of heritability of type 2 diabetes (T2D) has been attributed to inherent genetics. Recent genetic studies, especially genome-wide association studies (GWAS), have identified a multitude of variants associated with T2D. It is thus reasonable to question if these findings may be utilized in a clinical setting. Here we briefly review the identification of risk loci for T2D and discuss recent efforts and propose future work to utilize these loci in clinical setting—for the identification of individuals who are at particularly high risks of developing T2D and for the stratification of specific health-care approaches for those who would benefit most from such interventions. ASTAR (Agency for Sci., Tech. and Research, S’pore) Published version 2015-12-10T04:58:04Z 2019-12-06T14:19:20Z 2015-12-10T04:58:04Z 2019-12-06T14:19:20Z 2015 Journal Article Dorajoo, R., Liu, J., & Boehm, B. O. (2015). Genetics of Type 2 Diabetes and Clinical Utility. Genes, 6, 372-384. 2073-4425 https://hdl.handle.net/10356/81003 http://hdl.handle.net/10220/39027 10.3390/genes6020372 26110315 en Genes © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). 13 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Type 2 diabetes
Genetics
Clinical utility
spellingShingle Type 2 diabetes
Genetics
Clinical utility
Dorajoo, Rajkumar
Liu, Jianjun
Boehm, Bernhard Otto
Genetics of Type 2 Diabetes and Clinical Utility
description A large proportion of heritability of type 2 diabetes (T2D) has been attributed to inherent genetics. Recent genetic studies, especially genome-wide association studies (GWAS), have identified a multitude of variants associated with T2D. It is thus reasonable to question if these findings may be utilized in a clinical setting. Here we briefly review the identification of risk loci for T2D and discuss recent efforts and propose future work to utilize these loci in clinical setting—for the identification of individuals who are at particularly high risks of developing T2D and for the stratification of specific health-care approaches for those who would benefit most from such interventions.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Dorajoo, Rajkumar
Liu, Jianjun
Boehm, Bernhard Otto
format Article
author Dorajoo, Rajkumar
Liu, Jianjun
Boehm, Bernhard Otto
author_sort Dorajoo, Rajkumar
title Genetics of Type 2 Diabetes and Clinical Utility
title_short Genetics of Type 2 Diabetes and Clinical Utility
title_full Genetics of Type 2 Diabetes and Clinical Utility
title_fullStr Genetics of Type 2 Diabetes and Clinical Utility
title_full_unstemmed Genetics of Type 2 Diabetes and Clinical Utility
title_sort genetics of type 2 diabetes and clinical utility
publishDate 2015
url https://hdl.handle.net/10356/81003
http://hdl.handle.net/10220/39027
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