Genome and transcriptome delineation of two major oncogenic pathways governing invasive ductal breast cancer development

• Main Authors: Aswad, Luay, Yenamandra, Surya Pavan, Ow, Ghim Siong, Grinchuk, Oleg, Ivshina, Anna V., Kuznetsov, Vladimir A.
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: Invasive ductal carcinoma; Low and high genetic grades; Genome and transcriptome alterations; Mutations; Oncogenic pathway
• Online Access: https://hdl.handle.net/10356/81038; http://hdl.handle.net/10220/39116
• Institution: Nanyang Technological University

Invasive ductal carcinoma (IDC) is a major histo-morphologic type of breast cancer. Histological grading (HG) of IDC is widely adopted by oncologists as a prognostic factor. However, HG evaluation is highly subjective with only 50%–85% inter-observer agreements. Specifically, the subjectivity in the...