Synthesis and in vivo magnetic resonance imaging evaluation of biocompatible branched copolymer nanocontrast agents

• Main Authors: Jackson, Alexander W., Chandrasekharan, Prashant, Shi, Jian, Rannard, Steven P., Liu, Quan, Yang, Chang-Tong, He, Tao
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: MRI; RAFT polymerization; branched copolymer nanoparticles; gadolinium chelate
• Online Access: https://hdl.handle.net/10356/81040; http://hdl.handle.net/10220/39076
• Institution: Nanyang Technological University

Branched copolymer nanoparticles (Dh =20–35 nm) possessing 1,4,7, 10-tetraazacyclododecane-N,N',N",N'"-tetraacetic acid macrocycles within their cores have been synthesized and applied as magnetic resonance imaging (MRI) nanosized contrast agents in vivo. These nanoparticles have...