Aβ1-25-Derived Sphingolipid-Domain Tracer Peptide SBD Interacts with Membrane Ganglioside Clusters via a Coil-Helix-Coil Motif

• Main Authors: Wang, Yaofeng, Kraut, Rachel, Mu, Yuguang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: Sphingolipid binding domain; Lipid rafts; Molecular dynamics simulation
• Online Access: https://hdl.handle.net/10356/81043; http://hdl.handle.net/10220/39068
• Institution: Nanyang Technological University

The Amyloid-β (Aβ)-derived, sphingolipid binding domain (SBD) peptide is a fluorescently tagged probe used to trace the diffusion behavior of sphingolipid-containing microdomains in cell membranes through binding to a constellation of glycosphingolipids, sphingomyelin, and cholesterol. However, the...