Smooth Muscle Cell Alignment and Phenotype Control by Melt Spun Polycaprolactone Fibers for Seeding of Tissue Engineered Blood Vessels

• Main Authors: Agrawal, Animesh, Lee, Bae Hoon, Irvine, Scott Alexander, An, Jia, Bhuthalingam, Ramya, Singh, Vaishali, Low, Kok Yao, Chua, Chee Kai, Venkatraman, Subbu Subramanian
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/81091; http://hdl.handle.net/10220/39072
• Institution: Nanyang Technological University

A method has been developed to induce and retain a contractile phenotype for vascular smooth muscle cells, as the first step towards the development of a biomimetic blood vessel construct with minimal compliance mismatch. Melt spun PCL fibers were deposited on a mandrel to form aligned fibers of 10 ...