Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study

• Main Authors: Lim, Kah Wai, Jenjaroenpun, Piroon, Low, Zhen Jie, Khong, Zi Jian, Ng, Yi Siang, Kuznetsov, Vladimir Andreevich, Phan, Anh Tuan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: Physics & Applied Physics; Biological Sciences
• Online Access: https://hdl.handle.net/10356/81102; http://hdl.handle.net/10220/39095
• Institution: Nanyang Technological University

Duplex stem-loops and four-stranded G-quadruplexes have been implicated in (patho)biological processes. Overlap of stem-loop- and quadruplex-forming sequences could give rise to quadruplex–duplex hybrids (QDH), which combine features of both structural forms and could exhibit unique properties. Here...