TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification

TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification

The tumor suppressor ARF enhances the SUMOylation of target proteins; however, the physiological function of ARF-mediated SUMOylation has been unclear due to the lack of a known, associated E3 SUMO ligase. Here we uncover TRIM28/KAP1 as a novel ARF-binding protein and SUMO E3 ligase for NPM1/B23. AR...

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Bibliographic Details
Main Authors: Neo, Shu Hui, Itahana, Yoko, Alagu, Jennifer, Kitagawa, Mayumi, Guo, Alvin Kunyao, Lee, Sang Hyun, Tang, Kai, Itahana, Koji
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2015
Subjects:
Biological Sciences
Online Access:https://hdl.handle.net/10356/81114
http://hdl.handle.net/10220/39109
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/81114
http://hdl.handle.net/10220/39109

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