Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide–quadruplex complex

• Main Authors: Heddi, Brahim, Cheong, Vee Vee, Martadinata, Herry, Phan, Anh Tuân
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: G-quadruplex; DHX36; DEAH-box family; NMR; RHAU helicase
• Online Access: https://hdl.handle.net/10356/81172; http://hdl.handle.net/10220/39145
• Institution: Nanyang Technological University

Four-stranded nucleic acid structures called G-quadruplexes have been associated with important cellular processes, which should require G-quadruplex–protein interaction. However, the structural basis for specific G-quadruplex recognition by proteins has not been understood. The DEAH (Asp-Glu-Ala-Hi...