Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution

• Main Authors: Saw, Wuan Geok, Tria, Giancarlo, Grüber, Ardina, Subramanian Manimekalai, Malathy Sony, Zhao, Yongqian, Chandramohan, Arun, Srinivasan Anand, Ganesh, Matsui, Tsutomu, Weiss, Thomas M., Vasudevan, Subhash G., Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: Biological Sciences
• Online Access: https://hdl.handle.net/10356/81320; http://hdl.handle.net/10220/39216
• Institution: Nanyang Technological University

Infection by the four serotypes of Dengue virus (DENV-1 to DENV-4) causes an important arthropod-borne viral disease in humans. The multifunctional DENV nonstructural protein 5 (NS5) is essential for capping and replication of the viral RNA and harbours a methyltransferase (MTase) domain and an RNA-...