Gender differences in bronchiectasis: a real issue?

Gender differences in chronic respiratory disease, including cystic fibrosis and non-cystic fibrosis bronchiectasis are clinically apparent and of increasing importance. Differences in disease prevalence, severity and outcome are all described, however, the precise cause of the gender dichotomy and...

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Main Authors: Vidaillac, Celine, Yong, Valerie F.L., Jaggi, Tavleen K., Soh, ­ Min-Min, Chotirmall, Sanjay Haresh
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2018
Subjects:
Online Access:https://hdl.handle.net/10356/81398
http://hdl.handle.net/10220/45068
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-813982020-11-01T05:16:51Z Gender differences in bronchiectasis: a real issue? Vidaillac, Celine Yong, Valerie F.L. Jaggi, Tavleen K. Soh, ­ Min-Min Chotirmall, Sanjay Haresh Lee Kong Chian School of Medicine (LKCMedicine) Chronic Respiratory Disease Bronchiectasis Gender differences in chronic respiratory disease, including cystic fibrosis and non-cystic fibrosis bronchiectasis are clinically apparent and of increasing importance. Differences in disease prevalence, severity and outcome are all described, however, the precise cause of the gender dichotomy and their associated underlying mechanisms have been poorly characterised. A lack of dedicated clinical and epidemiological research focused in this area has led to a paucity of data and therefore a lack of understanding of its key drivers. Diagnosis, disease pathogenesis and treatment response are all complex but important aspects of bronchiectasis with an evident gender bias. Broadening our understanding of the interplay between microbiology, host physiology and the environment in the context of chronic lung diseases, such as bronchiectasis, is critical to unravelling mechanisms driving the observed gender differences. In this review, epidemiological, biological and environmental evidence related to gender in bronchiectasis is summarised. This illustrates gender differences as a “real issue” with the objective of mapping out a future framework upon which a gender-tailored medical approach may be incorporated into the diagnosis, monitoring and treatment of bronchiectasis. NMRC (Natl Medical Research Council, S’pore) Published version 2018-07-10T02:53:44Z 2019-12-06T14:30:05Z 2018-07-10T02:53:44Z 2019-12-06T14:30:05Z 2018 Journal Article Vidaillac, C., Yong, V. F., Jaggi, T. K., Soh, ­. M. M., & Chotirmall, S. H. (2018). Gender differences in bronchiectasis: a real issue?. Breathe, 14(2), 108-121. https://hdl.handle.net/10356/81398 http://hdl.handle.net/10220/45068 10.1183/20734735.000218 en Breathe © ERS 2018. Breathe articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. 14 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Chronic Respiratory Disease
Bronchiectasis
spellingShingle Chronic Respiratory Disease
Bronchiectasis
Vidaillac, Celine
Yong, Valerie F.L.
Jaggi, Tavleen K.
Soh, ­ Min-Min
Chotirmall, Sanjay Haresh
Gender differences in bronchiectasis: a real issue?
description Gender differences in chronic respiratory disease, including cystic fibrosis and non-cystic fibrosis bronchiectasis are clinically apparent and of increasing importance. Differences in disease prevalence, severity and outcome are all described, however, the precise cause of the gender dichotomy and their associated underlying mechanisms have been poorly characterised. A lack of dedicated clinical and epidemiological research focused in this area has led to a paucity of data and therefore a lack of understanding of its key drivers. Diagnosis, disease pathogenesis and treatment response are all complex but important aspects of bronchiectasis with an evident gender bias. Broadening our understanding of the interplay between microbiology, host physiology and the environment in the context of chronic lung diseases, such as bronchiectasis, is critical to unravelling mechanisms driving the observed gender differences. In this review, epidemiological, biological and environmental evidence related to gender in bronchiectasis is summarised. This illustrates gender differences as a “real issue” with the objective of mapping out a future framework upon which a gender-tailored medical approach may be incorporated into the diagnosis, monitoring and treatment of bronchiectasis.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Vidaillac, Celine
Yong, Valerie F.L.
Jaggi, Tavleen K.
Soh, ­ Min-Min
Chotirmall, Sanjay Haresh
format Article
author Vidaillac, Celine
Yong, Valerie F.L.
Jaggi, Tavleen K.
Soh, ­ Min-Min
Chotirmall, Sanjay Haresh
author_sort Vidaillac, Celine
title Gender differences in bronchiectasis: a real issue?
title_short Gender differences in bronchiectasis: a real issue?
title_full Gender differences in bronchiectasis: a real issue?
title_fullStr Gender differences in bronchiectasis: a real issue?
title_full_unstemmed Gender differences in bronchiectasis: a real issue?
title_sort gender differences in bronchiectasis: a real issue?
publishDate 2018
url https://hdl.handle.net/10356/81398
http://hdl.handle.net/10220/45068
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