Biomimetic three-dimensional anisotropic geometries by uniaxial stretch of poly(ɛ-caprolactone) films for mesenchymal stem cell proliferation, alignment, and myogenic differentiation

• Main Authors: Wang, Zu-yong, Teo, Erin Yiling, Chong, Mark Seow Khoon, Zhang, Qin-yuan, Lim, Jing, Zhang, Zhi-yong, Hong, Ming-hui, Thian, Eng San, Chan, Jerry Kok Yen, Teoh, Swee-Hin
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: Chemical and Biomedical Engineering
• Online Access: https://hdl.handle.net/10356/81400; http://hdl.handle.net/10220/17489
• Institution: Nanyang Technological University

Anisotropic geometries are critical for eliciting cell alignment to dictate tissue microarchitectures and biological functions. Current fabrication techniques are complex and utilize toxic solvents, hampering their applications for translational research. Here, we present a novel simple, solvent-fre...