Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants

• Main Authors: Papan, Cyrus, Osborne, Kathleen Amy, Torta, Federico, Shevchenko, Andrej, Schwudke, Dominik, Kraut, Rachel, Hebbar, Sarita, Sahoo, Ishtapran, Matysik, Artur, Garcia, Irene Argudo, Narayanaswamy, Pradeep, Fun, Xiu Hui, Wenk, Markus R
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2016
• 主題: Biological Sciences
• 在線閱讀: https://hdl.handle.net/10356/81549; http://hdl.handle.net/10220/39562

Sphingolipid metabolites are involved in the regulation of autophagy, a degradative recycling process that is required to prevent neuronal degeneration. Drosophila blue cheese mutants neurodegenerate due to perturbations in autophagic flux, and consequent accumulation of ubiquitinated aggregates. He...