Inducing ischemia-reperfusion injury in the mouse ear skin for intravital multiphoton imaging of immune responses

• Main Authors: Goh, Chi Ching, Li, Jackson LiangYao, Becker, David, Weninger, Wolfgang, Angeli, Veronique, Ng, Lai Guan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Medicine; DRNTU::Science::Medicine; Immunology
• Online Access: https://hdl.handle.net/10356/81564; http://hdl.handle.net/10220/47496
• Institution: Nanyang Technological University

Ischemia-reperfusion injury (IRI) occurs when there is transient hypoxia due to the obstruction of blood flow (ischemia) followed by a subsequent re-oxygenation of the tissues (reperfusion). In the skin, ischemia-reperfusion (IR) is the main contributing factor to the pathophysiology of pressure ulc...